REMDESIVIR
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REMDESIVIR
Subject: Science & tech
Context: India Bans Export of Anti-Viral Drug Remdesivir amid Surge in Covid Cases
Concept:
- Remdesivir is designed to obstruct the stage of replication, when the virus creates copies of itself, followed endlessly by the copies creating copies of themselves.
- Once the virus enters the human cell, it releases its genetic material, which is then copied using the body’s existing mechanism.
- At every stage of infection, various human proteins, virus proteins, and their interactions come into play.
- At the replication stage, the key viral protein at play is an enzyme called RdRp (an enzyme is a kind of protein that speeds up chemical reactions within a cell).
- It is RdRp that makes the copies, by processing components of the RNA of the virus.
- University of Alberta researchers called it the “engine” of the virus in a paper last week, in which they described the action of Remdesivir against this “engine”.
- In scientific literature, such an enzyme is called a polymerase (the p is RdRp stands for polymerase) or a replica.
- In any case, this is the enzyme that is targeted by Remdesivir.
