Plasmid DNA Vaccine
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Subject: Science and tech
Context:
ZyCOV-D is an indigenously developed plasmid DNA vaccine candidate for COVID 19 which has received approval for human trial.
Concept:
- DNA vaccines are considered as third-generation vaccines.
- The recombinant DNA technology plays an important role in the production of DNA vaccines.
- It involves the direct introduction into appropriate tissues of a plasmid containing the DNA sequence encoding the antigen(s) against which an immune response is sought, and relies on the in situ production of the target antigen.
- This approach offers a number of potential advantages over traditional approaches, including the stimulation of both B- and T-cell responses, improved vaccine stability, the absence of any infectious agent and the relative ease of large-scale manufacture.