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Lower oxygen at high altitudes increases lifespan in ageing mice

  • November 23, 2023
  • Posted by: OptimizeIAS Team
  • Category: DPN Topics
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Lower oxygen at high altitudes increases lifespan in ageing mice

Subject: Science and Tech

Section: Health

Context:

  • The lower oxygen content at high altitudes increases lifespan significantly in ageing mice, according to a study published in PLOS Biology.

Details of the study:

  • The study shows that oxygen restriction, or continuous hypoxia, can extend lifespan in an ageing mammal.
  • Naked mole rat: A rodent that spends most of its life in an oxygen-deficient burrow with a lifespan much longer than scientists have been able to predict based on its size or evolutionary history.
  • Caloric restriction, or dietary restriction without malnutrition is the gold standard for increasing lifespan in diverse species like yeast, roundworms, fruit flies, mice, and rats.
  • The animals housed in hypoxic conditions also displayed better neurologic function than their counterparts living in normoxic conditions (normal oxygen conditions).
  • The mechanism by which hypoxia extends lifespan in mammals is still unknown to researchers.

Significance of the study:

  • The study provides valuable insights into the potential of hypoxia to enhance healthy lifespan.
  • Ageing is a highly complex phenomenon, involving numerous molecular mediators. Hypoxia may not target many aspects of ageing since it doesn’t affect the expression of a gene (p21) that’s an important marker of ageing.
  • Applicability to humans:
    • There is no evidence of its applicability to the human population and ​​there is no evidence that people living at high altitudes have a longer maximal lifespan, but there are some clues that the median lifespan might be increased at higher altitudes.

Source: The Hindu

Lower oxygen at high altitudes increases lifespan in ageing mice Science and tech

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