inStem’s fabric offers protection from pesticides

Sub: Science and tech

Sec: Health

Context:

Researchers at the Institute for Stem Cell Science and Regenerative Medicine (inStem) developed an anti-insecticide fabric to neutralize organophosphate-based pesticides, building upon earlier work on topical gels for pesticide detoxification.

Details:

The fabric, coated with nucleophile small molecules covalently bonded to cellulose, effectively deactivates pesticides on contact through hydrolysis.
The fabric attacks the pesticide molecule and breaks it into non-toxic products. The pesticide is deactivated even before it reaches the skin surface.
Developed in collaboration with Sepio Health Pvt Ltd, the fabric remains durable and breathable while preventing pesticide-induced toxicity.
Developing a universal nucleophile capable of deactivating various pesticides and optimizing fabric attachment were critical steps in fabric development, ensuring practicality and effectiveness.

Mechanism of Action:

Organophosphate pesticides inhibit acetylcholinesterase (AChE), crucial for neuromuscular function, leading to various health issues.
Fabric-coated small molecules hydrolytically deactivate pesticides, preventing AChE (acetylcholinesterase) inhibition (critical for neuromuscular function) and subsequent health problems.
The fabric retains its anti-insecticide properties through 150 wash cycles, offering a long-term, cost-effective solution for farmers.
Unlike previous gels, the fabric’s reusability enhances affordability and compliance among users.

Potential Impact on Agriculture:

The fabric has potential to prevent chronic toxicity in farmers repeatedly exposed to pesticides, suggesting a significant health benefit and potential cost savings.

Source: TH