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TB Alliance

  • September 6, 2021
  • Posted by: OptimizeIAS Team
  • Category: DPN Topics
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TB Alliance

Subject: Science and Technology

Context: In Indian drugmaker has been roped-in by TB Alliance to make its tuberculosis drug pretomanid and strengthen global supplies.

Concept:

  • TB Alliance is a not-for-profit product development partnership (PDP), uniquely positioned to leverage a global network of public and private partners to most efficiently advance TB drug development.
  • A PDP builds partnerships between the public, private, academic, and philanthropic sectors to drive the development of new products for underserved markets.
  • PDPs retain direct management oversight of their projects, though much of the laboratory and clinical work is done though external research facilities and contractors.
  • This model minimizes costs, including overhead and investments in infrastructure, while optimizing scientific capability to speed new TB drug development.
  • In 2019, TB Alliance became the first not-for-profit organization to develop and register an anti-TB drug.
  • TB Alliance is a non-profit drug developer and its pretomanid is the third new drug developed for TB in over 40 years, after bedaquiline (from Johnson and Johnson) and delaminid (from Otsuka Pharmaceutical).
  • TB Alliance’s President, had indicated that a collaboration was in the offing with an Indian drug marker to shore-up global supplies.
  • Pretomanid is part of a three drug regimen that includes bedaquiline and linezolid and is used to treat those with extensive drug-resistant TB (XDR-TB) or multidrug-resistant TB (MDR-TB), who are treatment-intolerant or non-responsive.

Science and tech TB Alliance

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