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AI-Based Platform Revolutionizes Search for Age-Defying Molecules

  • December 11, 2024
  • Posted by: OptimizeIAS Team
  • Category: DPN Topics
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AI-Based Platform Revolutionizes Search for Age-Defying Molecules

Sub : Sci

Sec: Health 

Why in News

  • Researchers from the Indraprastha Institute of Information Technology (IIIT), Delhi have developed AgeXtend, an Artificial Intelligence (AI)-based platform. The platform accelerates the discovery of molecules with geroprotective properties (age-defying characteristics), marking a significant milestone in longevity research.

AgeXtend:

  • Researchers from the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi).
  • AgeXtend is an AI-driven platform designed to identify molecules that promote healthy ageing by targeting biological mechanisms associated with ageing.
  • Utilizes bioactivity data from known Gero protectors to predict the Gero protective potential of new compounds.
  • Key Features:
    • Prediction of Gero protective properties.
    • Toxicity evaluation.
    • Identification of target proteins and mechanisms of action.
  • Demonstrated success in identifying compounds like metformin and taurine as longevity enhancers, even when excluded from training data.
  • Screened around 1 billion compounds to identify promising candidates.
  • Tested the selected compounds on yeast, Caenorhabditis elegans, and human cell models to validate their effects.
  • Explores the role of human microbiome-derived metabolites in regulating cellular senescence.
  • Enhances understanding of previously unknown mechanisms influencing ageing.
  • AgeXtend represents a breakthrough in the integration of AI and biology for therapeutic discoveries.

Gero protective Property:

  • A geroprotective property refers to the ability of a substance, compound, or intervention to slow down, prevent, or reverse aspects of the biological ageing process, thereby promoting longevity and improving health span.
  • Gero protectors typically target specific mechanisms associated with ageing at the cellular, molecular, or systemic levels.
  • Mechanisms of Action:
    • Delay cellular senescence (the process where cells stop dividing and accumulate).
    • Reduce oxidative stress and inflammation.
    • Enhance autophagy (cellular cleanup processes).
    • Improve mitochondrial function and energy production.
  • Applications:
    • Treatment of age-related diseases such as neurodegeneration, cardiovascular issues, and metabolic disorders.
    • Extension of health span (the period of life spent in good health) rather than just lifespan.
AI-Based Platform Revolutionizes Search for Age-Defying Molecules Science and tech

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