- July 10, 2022
- Posted by: OptimizeIAS Team
- Category: DPN Topics
Subject: Science and technology
In 2019, when Immuneel Therapeutics Ltd, founded by Pulitzer winning author and US oncologist Dr Siddhartha Mukherjee and leading biotech entrepreneur Kiran Mazumdar Shaw, planned to set up a breakthrough cell therapy facility for
Chimeric antigen receptor T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. Chimeric antigen receptors are receptor proteins that have been engineered to give T cells the new ability to target a specific protein.
- An 11-year-old has become the first patient to receive CAR-T therapy (immunotherapy) that uses the body’s own cells to fight cancer.
- CAR-T is a personalized form of cancer treatment.
- CAR-T involves removing immune cells and modifying them in a laboratory so they can recognize cancer cells.
- Immunotherapy is treatment that uses your body’s own immune system to help fight cancer.
- First, the patient has blood removed and the white blood cells are separated out, with the rest of the blood being returned to the patient.
- A harmless virus is used to insert genes into T-cells, a special type of immune cell.
- These genes cause the T-cells to add a hook on to their surface, known as a chimeric antigen receptor (CAR).
- These engineered CAR-T cells – programmed to recognize and destroy the patient’s cancer cells – are multiplied in huge numbers and then infused back into the patient.