Geroscience: the science related to ageing

Subject: Science and tech

Section: Health

‘Geroscience’ describes a field focused on aging-related studies. He has developed a blood test that can measure the rate of ageing by analyzing DNA methylation through an enzyme called ‘gerozyme.’
Research groups are exploring medications and techniques to manipulate this enzyme to potentially slow ageing.
Notably, studies suggest drugs like metformin and inhibitors of the enzyme TORC1 may enhance immunity and reduce infections in the elderly, with ongoing research into rapamycin’s potential benefits for longevity and disease management.
Additionally, Dr. Belsky’s research indicates that socioeconomic factors can influence DNA methylation rates, affecting ageing.
Complementary to these findings, the Columbia Aging Centre highlights the importance of a balanced diet in supporting brain health and reducing age-related decline, emphasizing proteins, healthy fats, and antioxidants.
This is particularly relevant in India, where a significant portion of the population is elderly, and such dietary components are readily available for diverse dietary preferences.

Inhibited by exercise:

Researchers at Stanford University have discovered a drug that enhances muscle strength in ageing or injured mice by blocking the action of an age-related enzyme, 15-PGDH, which increases in muscles with age and in neuromuscular diseases. This inhibition rejuvenates physical activity in aging mice.
Additionally, the Mayo Clinic enumerates seven benefits of regular physical activity, particularly for seniors, such as weight control, disease prevention, mood improvement, increased energy, better sleep, improved sexual health, and social interaction benefits.
Furthermore, research from Spain suggests that music may influence the same ageing-associated enzyme, offering potential as a treatment for dementia.
A 2020 study found that music could be a significant therapeutic strategy for dementia, and more recent research proposes that music can modulate gene expression related to age-related cognitive disorders.
This indicates a promising intersection of music therapy and neurology in managing ageing processes and related diseases.

Source: TH