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Solidarity Trials

  • June 6, 2020
  • Posted by: admin
  • Category: DPN Topics
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Subject: Science and tech

Context:

The World Health Organization said that clinical trials of the repurposed anti-malaria drug hydroxychloroquine for treatment of covid-19 will resume, after a committee reviewed the available data for the drug.

Concept:

  • Solidarity” is an international clinical trial to help find an effective treatment for COVID-19, launched by the World Health Organization and partners.
  • The Solidarity trial will compare four treatment options against standard of care, to assess their relative effectiveness against COVID-19.
  • By enrolling patients in multiple countries, the Solidarity trial aims to rapidly discover whether any of the drugs slow disease progression or improve survival.
  • Over 90 countries including India are working together to find effective therapeutics as soon as possible, via the trial.
  • Four treatment options:
  1. The chloroquine-hydroxychloroquine combination to prevent entry of virus using ACE 2 receptor
  2. Lopinavir-ritonavir to prevent replication of virus by inhibiting enzymes used for replication
  3. By understanding structure
  4. By understanding virus behavior
  • WHO says that while randomized clinical trials normally take years to design and conduct, the Solidarity Trial will reduce the time by 80%.
  • The Union health ministry has permitted the trial for four drugs: Remdesivir, Lopinavir, Interferon (beta-1a) and hydroxychloroquine or chloroquine.
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